Proteomic Analysis in Nifedipine Induced Gingival Overgrowth: A Pilot Study
نویسندگان
چکیده
Objective: The aims of the present study were to investigate proteomic profile nifedipine induced overgrown gingiva and compare with non-overgrown gingival tissues obtained from same patients. Methods: Seven subjects under medication for at least 6 months diagnosed as overgrowth (NIGO) participated in study. Periodontal clinical parameters recorded. Gingival tissue samples harvested (GO+ Group, n=7) regions (GO- Proteomics was performed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) technique. identified proteins further classified according their molecular functions, biological processes cellular component distribution functional gene ontology analysis a web-based bioinformatics tool. Mann Whitney-U ANOVA tests proteomics, respectively. Results: Bleeding on probing index GO+ group statistically significantly higher than GO- (p
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ژورنال
عنوان ژورنال: Clinical and Experimental Health Sciences
سال: 2022
ISSN: ['2459-1459']
DOI: https://doi.org/10.33808/clinexphealthsci.1050418